During Prototype 2 there will be side missions that you will need to complete for various reason. These side missions are called blacknet missions that you need to complete or unlocked progresevely through the game's main story mode as you complete or reach certain points in the game. There is a total 12 blacknet missions that you will need to complete to upgrade James power to the fullest. Follow the Prototype 2 Blacknet Missions Walkthrough to unlock all the necessary mutation.
As you complete any blacknet mission you will unlock a new mutation which go along with the collectibles that help James become more powerful. During these blacknet side missions you will also need to collect in the different types of zones, yellow, green and red the
When you are unlocking the blacknet side missions for example, one of the mission will be just on stealth and others will be on collecting or combat. Also you will be able to use Heller's pack leader ability which you control other infected but powerful enemies to go and complete different types of task by destroying tanks, helicopters and many other task. Need additional help to locating other people to complete the missions then take a look at the prototype 2 walkthrough, blackboxes, lair and field ops locations to help you complete them.
Prototype 2 Blacknet Missions Walkthrough